Sentence examples for binding pocket adjacent to from inspiring English sources

The results from the molecular modelling studies suggest that 2-BFI binds to B-CK in a cleft or a binding pocket adjacent to the active site.

In this structure, amino acid residues Gln101, Asp172, Gln173, Arg178, Arg180 and Arg183 were shown to be critical for CGPase activity and for the formation of a conserved binding pocket adjacent to the catalytic Ser132.

The most common somatic POLE mutation (p.Arg286His) localises to the DNA binding pocket adjacent to the exonuclease active site, probably perturbing the structure of the DNA binding pocket.

The activity of B-CK was inhibited by BU99006 and the molecular modelling predicted, with high probability, a binding pocket adjacent to the active site of B-CK.

The discovery of an allosteric binding pocket adjacent to the ATP-binding site led to the discovery of inhibitors using both sites (type II).

In typical ACADs (for example, the well-characterized MCAD), there are four acyl-CoA binding pockets adjacent to four FAD cofactors.

Structural analysis of MEK1 and MEK2 with PD184352, a putative non-competitive inhibitor, has revealed that the molecules possess a unique allosteric inhibitor-binding pocket adjacent to, but separate from, the ATP-binding site [23].

The binding site for this fragment has not been conclusively determined, but the weak PRE signal and modeling of the probe in complex with Lck predicted that it binds in a pocket adjacent to the ATP binding site and the substrate binding site.

Nevirapine acts by binding to a hydrophobic pocket adjacent to the catalytic site of HIV-1-RT [31], [32].

We simultaneously reported about (S -PCEP an agoniS -PCEPubtype 4 mGluR than would bind to agonistar pofket, adjacent to the glutamate binding subtype

Although many kinase inhibitors target the ATP-binding region of an enzyme, MEK contains a hydrophobic allosteric pocket adjacent to the ATP-binding site that is not shared with other kinases.