Sentence examples for binding site adjacent to from inspiring English sources
TCFs interact with SRF and simultaneously bind to an ETS binding site adjacent to the CArG box.
For the cytokine interleukin-2 (IL2), Tethering identified a binding site adjacent to the IL2/IL2-receptor and a new site allosterically coupled to this PPI.
A striking example is provided by recent crystal structures of the p38 MAP kinase, where a 10 Å movement of the Phe169 side-chain creates a new binding site adjacent to the ATP binding site that is exploited by the diaryl urea inhibitor BIRB796.
The majority of kinase inhibitors developed to date are competitive inhibitors that target the ATP binding site; however, recent crystal structures of Gleevec® (imatinib mesylate, STI571, PDB: 1IEP), Nexavar® (Sorafenib tosylate, BAY 43-9006, PDB: 1UWJ), and BIRB-796 (PDB: 1KV2) have revealed a secondary binding site adjacent to the ATP binding site known as the DFG-out allosteric binding site.
Some CDK2 ligands that have a sulfonamide group that is positioned to interact with a lysine residue (Lys 89) on the top edge of the binding site, adjacent to a phenyl ring (Phe 82) that packs into a small secondary hydrophobic pocket or slot above the hinge region (Figure 8A).
Finally, our recent structural and biochemical studies showed that residues 212 to 222 of Pak1 encode an LC8 binding site adjacent to the nuclear localization site (Fig. 1A) [9].
Binding sites located near a functional σ promoter may serve to accelerate the search for the promoter by Eσ sliding from the secondary sites [ 50]; while binding sites adjacent to, or overlapping, a σ- or σ-promoter may bind Eσ or σ and repress or activate transcription from the other promoter [ 51].
This may be related to the inability of both neomycins of neo-neo it find optimal binding sites adjacent to one another without changing RNA structure.
Work from MacAlpine and colleagues has shown that yeast origins correlate very strongly with ORC binding sites adjacent to AT-rich sequences which exclude nucleosomes (Eaton et al, 2010).
To test the possible direct regulation of predicted E2F target genes by E2F2, we preformed ChIP analysis in MCF-7 cells and observed strong binding of E2F2 to the predicted binding site in the promoter region of the CDC25A gene, and the binding was comparable to known E2F2 binding sites adjacent to CASP3 and EZH2.
