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Exact(5)
The regulation of localization of FAK and Pyk2 to focal adhesions can be independently influenced by the presence or absence of specific binding partners, for example, gelsolin has been reported to bind Pyk2 but not FAK [40] as well as differences in the affinity of FAK and Pyk2 for shared binding partners within the focal adhesions, such as paxillin [41] [43].
In these studies, high-affinity binding partners, for example biotin − (strept avadin and/or digoxin − anti-digoxin antibodies were used.
One future avenue of research will be the identification of putative binding partners, for example by bioinformatic analysis, searching for genes with similar phylogenetic profiles as those of the inserted domains.
The same principle of methodology could be very useful in addressing proteomic questions, such as rapid screening of the maize proteome for binding partners, for example proteins involved in hormone regulation or defence.
Faster association has been attributed to increased electrostatic attraction between the binding partners, for example, for binding between TEM1 beta-lactamase and its protein inhibitor BLIP [ 53], but it can also originate from mutations of noninterfacial residues as in study [ 54].
Similar(54)
It is clear that many commonly observed co-operative motif pairings reflect the available motif-binding pockets in the binding partner, for example, docking motifs and modification sites for the same PTM enzyme will often occur in the same protein, increasing the efficiency and specificity of modification [ 78, 80, 103– 103].
When their interactions with other proteins have been dissected, the different PDZ domains of a single protein often have been found to have distinct binding partners (see for example the Uniprot entry for MPDZ [ 13]).
For example, multiple lysine PTM sites contribute to various activities of p53 [31]–[33], and it is possible that novel binding partners for PTMs of p53 and other proteins in diverse organisms can be identified using array methods as described here.
For example, Hall and coworkers demonstrated in this way that the C-termini of GPCR proteins such as P2Y1R, mGluR5, and β1AR are binding partners for several PDZ domains [ 28- 30].
We used yeast two-hybrid analysis to identify potential protein binding partners for human TTP (hTTP).
These two proteins may represent novel binding partners for Tspan9.
Related(16)
binding strengths for example
binding partners for dystroglycan
binding partners for psoriasin
binding partners for novel
binding carbohydrates for example
binding partners for galectin-3
binding partners for tTG
binding capacities for example
binding partners for periostin
binding pockets for example
binding partners for degradation
binding sensors for example
binding sites for example
binding partners for c-CBL
binding motifs for example
binding properties for example
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