Sentence examples for binding sites for example from inspiring English sources

These findings further indicate that other factors may contribute to or modulate the functionality of PUM binding sites, for example recognition elements for cofactors like Nanos, which is known to interact with Pumilio to mediate translational repression [55].

A number of projects have combined data of several types to predict binding sites: for example [ 19- 21].

In silico promotor analyses of the KIAA1199 promoter region identified binding sites, for example, TP53, LEF1/TCF or SMAD4 (Supplementary Table 2).

Among homologous human and rodent TF binding sites, for example, Dermitzakis and Clark [ 65] found 33 with shared functions, while 14 were human-specific and 17 rodent-specific.

Alternatively, we cannot exclude that condensin engages in interactions not only between its binding sites, but also with chromatin features between binding sites, for example, histones (Tada et al., 2011).

A PDB entry can have more than one protein-DNA binding sites; for example, 1A02 has two distinct protein-DNA binding entities on one double-stranded DNA (NFAT-DNA and FOS-JUN-DNA).

Furthermore, substituting an amino acid at a binding site, for example, can disrupt ionic quaternary interactions, rather than disrupting the protein fold.

Labeling experiments are very helpful if an accessible position can be identified for insertion of a binding site, for example, a unique cysteine for binding a derivatized gold particle, or fusion of a protein domain such as GFP.

Other algorithms use a collection of subsequences containing a binding site (for example the promoter regions of coregulated genes or subsequences derived from ChIp-chip experiments) to deduce the form or motif of the binding site which is then used to identify sites in other sequences — reviews of these methods are given in [ 7, 8].

This conclusion is significant since one possible explanation for the observed phenomenon is that the region is conserved at the nucleotide level rather than at the amino acid level, such as would be the case for something like a microRNA binding site, for example.

It is worth mentioning that we identified neighbouring genes showing significantly altered expression according to our expression data, which could be simultaneously regulated by a unique Pax8 binding site; for example, the closely positioned genes Padi1 and Padi3 (peptidyl arginine deiminase, types I and III) on chromosome 5, and Mlph (melanophilin) and Rab17 on chromosome 9 (Additional file 12).