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A series of mono-1H-benzo[c,d]indol-2-one with different amine side chains and bis-1H-benzo[c,d]indol-2-one as novel family of DNA intercalators were designed and synthesized, the contributions of aromatic chromophores and amine side chains for DNA binding properties, for example, intercalation and electrostatic binding, respectively, were evaluated.
Previous studies have established that 5-mC and 5-hmC-containing DNAs have different protein binding properties; for example, the interaction of MBD proteins with 5-mC is abolished by hydroxymethylation.
Similar(58)
It is also notable that the PAKKA repeats significantly alter DNA-binding properties, for example, conferring on Hlp the ability to promote DNA end-joining and directing D. radiodurans HU to an unusual binding mode with four-way junction DNA [ 4, 6].
For example, are the trafficking/display patterns [ 54] of HA receptors that have differential binding properties for discrete sizes of HA fragments involved in signal transduction of the HA fragment pool as a whole?
Thus, random substitutions of the PA-binding domain may reveal peptides with significantly enhanced binding properties for FluA-PA.
These results indicate that Josephin dictates preferential binding properties for different Ub linkages.
Altered binding properties for the DSG2 A517V change were not identified.
Nevertheless, it is likely that the three conformers have slightly different properties, for example binding affinity for other proteins.
Grouping different sequences with similar structural properties for example, will always be more difficult for sequence-based methods, as was shown for predicting prokaryotic TF binding sites.
Closure certainly does hold for some properties, for example, truth.
In such cases, there is no entailment; thermal conductivity properties do not entail electrical conductivity properties, for example.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com