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This regimen was based on rodent studies, where irradiation effectively suppressed neurogenesis without causing significant necrosis or behavioral side effects [18], [19], [20].
In this review, I will examine the literature, largely based on rodent studies, that is beginning to shed some light on the mechanisms that underpin hypoglycemia detection.
Given the lack of dose-response data for human neurotoxicity, the risk assessment was based on rodent studies and supported by primate studies of acrylamide neuropathy.
The first set of models, exploring the glucagon counterregulation mechanism, were proposed by Farhy and McCall, (S127, S128) based on rodent studies.
In agreement with preclinical studies of chronic stress, decreases in CA3 volumes were shown [ 90] that, based on rodent studies, it could be related to different structural substrates, as will be discussed below.
This hypothesis was based on rodent studies of trace and context fear conditioning that have shown a contribution of the MPFC/ACC to the recall of remote fear memories (Takehara et al. 2003, Frankland et al. 2004; Runyan et al. 2004).
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Background: Current thinking, which is based mainly on rodent studies, is that physiologic doses of folic acid (pterylmonoglutamic acid), such as dietary vitamin folates, are biotransformed in the intestinal mucosa and transferred to the portal vein as the natural circulating plasma folate, 5-methyltetrahydrofolic acid (5-MTHF) before entering the liver and the wider systemic blood supply.
Based on rodent and pig studies, it is reasonable to assume that OTA, at high-enough exposures, would cause similar toxicities in humans.
First, our observations are solely based on rodent models.
Much of the research examining the safety of pediatric vaccines is based on rodent data.
In a phase I trial based on these rodent studies, nine patients with inflammatory breast cancer were placed on a similar regimen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com