Sentence examples for based on rat studies from inspiring English sources

According to a risk assessment by the E.P.A., the estimated range of exposure for human beings, based on rat studies, overlapped with what the E.P.A. deemed unacceptable for toxic substances.

The dose of lovastatin was based on rat studies in ADPKD [ 12] and experimental nephrotic syndrome [ 16].

This suspicion was based on rat studies that indicated that perhaps anemia has a nephro-protective effect and the correction of it would accelerate renal injury [ 1, 2].

This is based on rat studies, which demonstrated that vismodegib administered at a dose of 10 mg/kg/day showed teratogenic effects.

In other words, the accepted toxicity rating for these pesticides and any consequent policy was false because it was based on rat studies that did not correctly predict toxicity in humans.

Based on rat studies, the critical phase for penile effects due to androgen suppression is during the male programming window, estimated to be within the MBP treatment period (∼7 15 weeks gestation) when extrapolated from rat and human (Welsh et al., 2008) and based on fetal testis development in the marmoset (Mitchell et al., 2008).

Although official RfDs have not been established for PFOA or PFOS, provisional RfDs based on rat carcinogenesis and multigenerational studies have been suggested (PFOS, 0.025 μg/kg/day; PFOA, 0.333 μg/kg/day) (Gulkowska et al. 2006).

Pharmacokinetic and pharmacodynamic studies based on rat models suggested these newly constructed nanoassemblies with low cytotoxicity may function as novel nanoplatforms to efficiently and safely deliver therapeutics to achieve better efficacy but lower side effects.

The cancer no-effect levels for glyphosate, based on rat and mouse lifetime feeding studies, are 1,000 and 1,500 mg/kg/day, respectively (Williams et al. 2000).

The studies are based on rat gliomas with high apoptotic activity and homogeneous tissue composition compared to human tumors.

Additionally, established broad knowledge and promising results based on rat wound healing earned from previous studies are the main reason for rat utilizing.