Sentence examples for based on preclinical models from inspiring English sources

It is critical to develop biomarkers at the earliest stages of drug discovery and, where based on preclinical models, translate them effectively into the clinic.

This phase II study was designed to evaluate the efficacy and safety of erlotinib and enzastaurin in NSCLC, a combination with promise to overcome EGFR resistance based on preclinical models.

2ME2 levels were substantially below those required for activity based on preclinical models.

Yet for most major diseases, clinical trials based on preclinical models show a very low success rate.

However, the factor(s) that we think will be important for drug activity based on preclinical models may end up not being the ideal or relevant target, as was the case with EGFR IHC expression for EGFR TKIs in NSCLC and for cetuximab in colorectal cancer [ 137].

Based on preclinical models, dual inhibition of both IGF1R - with either monoclonal antibodies or tyrosine kinase inhibitors - and mTOR results in a superior antiproliferative effect over each single strategy [ 5], and this combination is now being explored in phase I/II trials in patients with breast cancer.

Another approach to optimizing targeted therapy involves selecting a chemotherapy regimen with the greatest potential for synergy based on preclinical modeling.

The next generation of human clinical trials for plexiform neurofibromas will be heavily based on preclinical modeling.

In that sense, the scientific community has now to take a step back as the clinical outcome highlighted by the most recent clinical trials has only partially mirrored the expected results based on preclinical animal models, in terms of actual engraftment, survival, differentiation, and functional recovery.

Based on preclinical laboratory modelling, we have translated the new biology of oestrogen action into a Department of Defense Center of Excellence grant with laboratory and clinical collaborators illustrated in Figure 1.

The 0.1 mg/kg dose was chosen as the starting dose on the basis of multiple-dosing preclinical toxicology findings in cynomolgus monkeys; the remaining doses were based on preclinical pharmacokinetic modeling and toxicology studies that showed no adverse effects (AEs) at weekly doses up to 150 mg/kg IV or SC [data on file].