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Based on preclinical studies and prior observations, it was suspected that diastolic dysfunction or pulmonary hypertension is predictive of hemodynamic benefit.
Although early programs targeting MMPs were largely unsuccessful in clinical trials, they remain a viable and highly desirable therapeutic target based on preclinical studies and their role in disease progression.
Biological endpoints will focus on the proposed mechanisms of action of the human MSCs in ARDS based on preclinical studies.
In addition, but mainly based on preclinical studies, volume resuscitation with hypertonic fluids may exert intrinsic beneficial effects by modulating the inflammatory response and apoptosis in trauma and sepsis; these effects however have not yet been convincingly shown in clinical studies [5, 6].
Thus far, all cancer vaccines in clinical trials are based on preclinical studies at young age.
The pulse voltages and duration are based on preclinical studies [ 4, 10] as well as clinical studies [ 10, 11].
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Radiolabelled somatostatin analogues have been tested as a single therapy for SCLC, but this has not been as promising as predicted, based on preclinical study results [17 19].
However, the aim of CT is usually the verification of the efficacy of a new treatment modality based on preclinical study and logical rationale that the CT therapy could be superior to or at least not inferior to conventional therapy.
In fact, results of clinical trials often fall short of hopes and expectations based on preclinical animal studies.
These observations are based on preclinical cancer studies, and it is not known how pervasive this problem may be in other disciplines, including environmental health research.
The data regarding ticagrelor based on preclinical and clinical studies are examined.
More suggestions(15)
based on available studies
based on cadaveric studies
based on small studies
based on recent studies
based on deep studies
based on preclinical data
based on preclinical models
based on independent studies
based on observational studies
based on phylogenetic studies
based on epidemiological studies
based on prospective studies
based on preclinical observations
based on flawed studies
based on neuroimaging studies
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