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Exact(4)
At the San Francisco site a lower proportion of participants took one or more of the assigned VivaGel® doses for ≥8 days (82%) in comparison to the placebo (100%), while at the Kisumu site a greater proportion of participants in the VivaGel® arm took one or more of the assigned doses for ≥8 days (92%) in comparison to the placebo (67%).
Patients were then switched to a PRN regimen at their originally assigned doses.
Attending physicians received envelopes with the assigned doses, which they then prescribed.
Assigned doses were as follows: Dieckmann, 12.4 g; Horne, 10.4 g; Boston/DESAD, 8.5 g; California/DESAD, 7.9 g; Baylor/DESAD, 2.6 g; Wisconsin/DESAD, 3.2 g; and Mayo/DESAD, 1.5 g.
Similar(56)
At the end of the evaluation period, more than 98% of patients successfully maintained hemoglobin within the target range and at their darbepoetin alfa assigned dosing frequency.
All CZP patients continued to receive the initially assigned dose.
CZP patients continued to receive the initially assigned dose [ 23].
On each blood sampling day, patients were asked to take their assigned dose of study drug with breakfast.
Once the toxicity decreased in severity to grade 1, the patient may have continued on the assigned dose.
All patients randomized to sildenafil received 10 mg 3 times daily for 1 week followed by titration to assigned dose.
In our initial analysis, we assigned exposure status using the actual number of doses that had dates recorded against them, ignoring provider assigned dose numbers.
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