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Exact(17)
The CpG array coverage also extends into gene bodies, downstream gene locations, and currently uncharacterized chromosomal regions.
CMA V4 also failed to identify one marker chromosome, but this could be due to the limited array coverage.
Variables such as array, coverage, intensity and CNV calling algorithms may all give different CNV calls.
Array coverage putatively correlates with copy number status of the region.
This method is not restricted by the array coverage or probe performance and thus allows a real genome-wide analysis.
Effectively, this means that for 78% of the targeted sequences on the array, coverage was sufficient (>20 × ) to detect any variants that were present.
Similar(43)
A number of different platforms are available for detection of CNVs, varying in their resolution (from ∼1 Mb for BAC arrays to a few kilobases for oligonucleotide and single nucleotide polymorphism arrays), coverage of the genome (targeted vs whole genome coverage) and source of comparator DNA.
Many people find the array of coverage options and pricing to be particularly confusing.
However, lack of annotation and therefore array probe coverage of this region apparently prevented recognition that this was a small RNA.
Unfortunately, the program was straining the state's budget, primarily due to its extensive array of coverage and lack of caps on pharmaceutical benefits [ 47].
The array includes coverage of 96% of CpG Islands and CpG shores, 99% of RefSeq genes, 94% of loci present on HM27K bead array, and additional CpGs identified as variable from various WGBS methylation investigations [ 15].
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