Exact(22)
This occurs at larger values of lipid raft coverage (Figure 6B).
There are other parameters (besides raft coverage) that also affect amplification ratio.
Although the parameters that were highly correlated did not differ much between 10% and 30% lipid raft coverage, a significantly distinct pattern of correlation was observed for 2% lipid raft coverage.
This explains the negative correlation of khyd with amplification ratio at 10 and 30% lipid raft coverage (see Table 3).
Table 3 indicates the rank order of PRCC values for model parameters at three levels of lipid raft coverage.
These plots (and also Figures 6A, B) show that the amplification ratio significantly depends on lipid raft coverage.
Similar(38)
Both maximal effect and ligand potency increase (over the case of no lipid rafts) when lipid rafts at 2% coverage amplify the G-protein response.
On the other hand, when lipid rafts at 30% coverage are compared to the case of no lipid rafts, although maximal effect decreases, EC50 is not significantly affected.
Moreover, our modeling indicates that receptor localization within G-protein enriched lipid rafts with small coverage (∼2%) leads to signal amplification, consistent with experimental data on neurokinin 1 receptor signaling in HEK293 cells [63].
Greater enrichment of reactants in lipid rafts at 2% coverage leads to more rapid re-activation of G-protein following GTP hydrolysis compared with that in the non-raft region or when reactants are randomly distributed on the membrane due to lipid raft disruption.
The spokesman said Lord Wakeham would now look at "the raft of issues" concerning coverage of the premier's children that had been raised over the summer, including the reports of Euan's arrest last month for being "drunk and incapable" in central London.
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