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The first model used the standard %OD of 70% as the cut-off and all the prior information available from previous studies of the cELISA (Table 1) while the LFA was given non-informative beta(1,1) priors.
It is shown that the limit case where all available prior information is incorporated is tantamount to model-based design.
The BM method takes all available prior information on model inputs and outputs and, where available, likelihood functions for data and generates posterior distributions of model inputs and outputs through statistical comparisons of predictions with data.
These design decisions are intended in part to identify the most appropriate clinical niche for the product, using all prior information.
Conversely, the GWA approach discards all prior information, opening itself up to the problem of massively multiple testing.
However, these more empirical approaches cannot accommodate all prior information on both the drug and the physiology, thus restricting the ability to predict PK for a similar drug or to extrapolate the PK to different physiological conditions.
We provide a methodology that integrates the contribution of SLR with all other available prior information to determine uncertainty levels for failure analysis of the flood defenses.
Awesome tool! I started using it one year ago and I never had to look for another app
Ha Thuy Vy
MA of Applied Linguistic, Maquarie University, Australia