In addition, we identified additional mutation of the TP53 gene in anaplastic astrocytoma tissue but not in other benign tumors.
In KRAS-mutated samples, 20% had an additional mutation in PIK3CA.
In addition to this, the complementary Curated Short Read archive (CSR) project provides additional mutation data to BioMuta from TCGA.
Therefore, we examined the effects of an additional mutation in the carbohydrate-binding site on the specificity of the lectin.
Owing to the higher sensitivity, an additional mutation (T790M; including an ultra-low-level mutation, < 0.1%) was detected in the same reaction.
A genetic mutation usually leads to crippled and misfolded proteins, but in rare instances an additional mutation can bring a protein back to life.
An additional mutation, K839S, designed to disrupt the shared NTP-binding motif, nearly abolished the two-hybrid interaction and prevented virus replication, suggesting that NTP-binding and/or the structure of this motif is a contributing factor in the interaction.
As a second step to improve vaccine safety, an additional mutation (W1266A) was engineered in the ganglioside binding pocket, resulting in reduced receptor binding, to produce M-BoNT/A1W M-BoNT/A1W
We tested the effect of an additional mutation in the UL41 gene on d106 immunogenicity and found that it did not improve the efficacy of the d106 vector, in contrast with results from other studies with UL41 gene mutants.
Two sequences from China (AF502435 and AY249434) had an additional mutation at nucleotide position 119 from G → A which translated into an amino acid substitution from arginine to histidine.
An additional mutation at the C-terminus of the α-helix (Q162H or Q162Y) increased the half-life to 63 min. Mutations Q162H and Q162Y alone had a stabilizing effect at 55°C but not at 65°C.
