Sentence examples for extra mutation from inspiring English sources

An analysis of the relative efficiency of tumorigenesis with and without a somatic mutator mutation, in the absence of lineage expansion (LE), demonstrated that mutator mutations enhance tumorigenic efficiency under many realistic scenarios, despite the need for an extra mutation step to acquire the mutator mutation itself [15].

In the worm experiment, published by Leonard Guarente of the Massachusetts Institute of Technology in 2001, the strain of worms used had picked up an extra mutation that also had the effect of prolonging life, the London researchers report.

Where adding an extra mutation to the model increased this score, no further optimizations were carried out.

Again, ten clones were sequenced with all clones carrying in combination with the round 1 mutations E104K and G238S, an extra mutation, M182T (T->C transition) with no silent or other mutations.

In the last setting, with the highest increase in discriminative performance compared with the original CGC referral criteria, only three extra mutation carriers were identified in addition to those identified by the original CGC referral criteria (Supplementary Figure 2).

In the second, it acquired the five extra mutations, which Dr. Thornton called "restrictive" mutations.

In the grand scheme of things, the negative effect of extra mutations is likely to be countervailed by the positive effects of modern life: better nutrition, hygiene and sanitation, as well as better medical care.

The next step would be to perfect the system to enable precise base editing at a single base resolution with high efficiency, without introducing extra mutations.

But curiously, the tumor-suppressor protein made by the gene began to pick up extra mutations in and around the region that contains the T-to-A switch.

Some evolutionary biologists had suggested that if one strand was copied more faithfully, it would preserve genes, while extra mutations on the other strand might allow new and possibly advantageous features to spring up.

This mutant was then backcrossed three times with the wild-type strain to remove extra mutations.