Sentence examples for abnormal selection from inspiring English sources

Thus, the peripheral T cell phenotype in the Foxn1Δ/Δ mutants is the result of both direct effects of abnormal selection within the thymus, compounded by secondary effects of low T cell output and a hypocellular peripheral environment.

The TCR signalling defects in PKD2-null peripheral T-cells are therefore cell intrinsic and are not caused by abnormal selection of anergic peripheral T-cells.

Importantly, the peripheral memory BCR repertoire in SLE is shaped by abnormal selection, exaggerated somatic hypermutation, and increased receptor editing [ 15, 16].

It is also unclear whether this predominance of memory B cells reflects a loss of peripheral tolerance or abnormal selection processes or whether their appearance is simply the result of an enhanced activation and differentiation of naïve B cells or their insusceptibility to immunosuppressive drugs.

Of importance, new information has made it possible to distinguish between the contribution played by abnormalities in central checkpoints that could lead to a pre-immune repertoire enriched in autoreactive B cells, on the one hand, and the possibility that autoimmunity arises in the periphery from somatic hypermutation and abnormal selection during T cell-dependent B-cell responses on the other.

It is currently unclear whether the predominance of IgD-CD27+ post-switched memory B cells reflects a loss of peripheral tolerance or abnormal selection processes or whether their appearance is simply the result of enhanced activation and differentiation of naïve B cells or the lack of susceptibility of memory B cells to immunosuppressive drugs.

Unnatural Selection.

To define how many transaction dates would be taken into consideration a Positive Abnormal Return selection window (days) was implemented (Fig. 2).

However, it is also possible that the peripheral T-cell defects observed in PKD2-null mice reflect that PKD2 loss results in abnormal thymocyte selection.

For example, at the Saccharomyces Genome Database (SGD), if the only experimental result for a gene were the mutant phenotype of abnormal bud site selection, we would annotate using a Biological Process term for 'cellular bud site selection' (GO 0000282).

MC was able to generate novel designs and gestures but his performance was highly perseverative, and his motor movement selection was abnormal, resembling a non-random pattern.