a significant alteration of

USAGE SUMMARY

The phrase "a significant alteration of" is correct and usable in written English.
It can be used when discussing a notable change or modification to something, such as a document, process, or system. Example: "The new policy represents a significant alteration of our previous guidelines, aiming to improve efficiency."

✓ Grammatically correct

Science

News & Media

Academia

Human-verified examples from authoritative sources

Exact Expressions

59 human-written examples

These changes are all well and good, but the most exciting part of the WTA map — for the casual fan — is a significant alteration of a ranking system that can only be described as byzantine.

The New York Times - Sports

CNS diseases such as Parkinson, schizophrenia, and attention deficit hyperactivity disorder (ADHD) are characterized by a significant alteration of dopamine transporter (DAT) density.

Bioorganic & Medicinal Chemistry

A significant alteration of microtubular architecture was equally observed in both stomach and colon cancer cells exposed to SdG (100 μg/ml).

Journal of Ethnopharmacology

That is a significant alteration of lending terms that would strengthen the negotiating hand of the bondholders if Greece eventually concluded it had no alternative but to default — even after this latest bailout.

The New York Times

Although the cellular cores compared in this study share the same mass-to-stiffness ratio, a significant alteration of the transition frequency and modal density can be observed compared to honeycomb cores.

Composite Structures

We replaced the two loops with segments of random amino acids, and used mRNA display to isolate variants that specifically recognize adenosine triphosphate (ATP), demonstrating a significant alteration of the function of this protein domain from DNA binding to ATP recognition.

Chemistry & Biology

Previous experimental studies of the encircling endocardial ventriculotomy (EEV) have shown a significant alteration of normal local electrical activity within the encompassed region.

Duke University

Dysfunctional remodeling has a significant alteration of the joint or occlusion and can cause reduction of condylar-ramus height, mandibular setback leading to class II malocclusion [55,56].

Maxillofacial Plastic and Reconstructive Surgery

As assumed, we did not find a significant change in luciferase activity in the ER Calux assay with T47Dluc cells nor a significant alteration of E2 production in H295R cells after treatment with MWCNT.

Nanoscale Research Letters

Our results demonstrated that the two-hit model showed a significant alteration of pulmonary function (gas exchange and respiratory system compliance), increase in PMN alveolar recruitment as index of inflammatory response, and alteration of alveolar capillary barrier.

Intensive Care Medicine Experimental

Human-verified similar examples from authoritative sources

Similar Expressions

1 human-written examples

In this study we have identified a significant alteration in expression of several genes involved in immune responses, most of them with links to neurological damage.

BMC Genomics

Expert writing Tips

Best practice

When using "a significant alteration of", ensure the context clearly indicates what is being altered and the impact of the alteration. Providing specific details will enhance clarity and avoid ambiguity.

Common error

Avoid using "a significant alteration of" when the change is minor or inconsequential. Overusing the phrase for trivial changes dilutes its impact and can mislead readers.

Linguistic Context

The phrase "a significant alteration of" functions as a noun phrase, typically acting as the subject or object of a sentence. It indicates that a particular element has undergone a substantial change. As Ludwig AI confirms, this is a standard construction in English.

Expression frequency: Very common

Frequent in

Science

79%

News & Media

15%

Academia

6%

Less common in

Formal & Business

0%

Ludwig's WRAP-UP

In summary, "a significant alteration of" is a versatile phrase used to denote a noteworthy change across various contexts. Ludwig AI confirms its grammatical correctness and frequent usage. While versatile, its formal tone aligns best with scientific, academic, and news-related content. When deploying "a significant alteration of", clarity and precision are key. Describe what has been altered and its impact on the surrounding context. Alternatives like "a substantial modification of" or "a major revision of" can be used to add variety while maintaining accuracy. Steer clear of overstating the significance to ensure your writing remains credible and impactful.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a substantial modification of

Emphasizes the degree of change, focusing on the tangible impact of the alteration.

a considerable adjustment to

Highlights that an adaptation or fine-tuning process has occurred.

a marked transformation in

Focuses on a visible or easily noticeable change in character or form.

a major revision of

Implies a comprehensive review and alteration of existing material.

a sweeping change to

Suggests a broad and extensive alteration affecting many aspects.

a drastic shift in

Indicates a sudden, extreme change in direction or approach.

a fundamental reshaping of

Highlights an alteration that affects the core structure or principles.

a profound alteration to

Emphasizes the depth and significance of the alteration's impact.

a noticeable difference in

Focuses on the perceptibility and ease of observing the change.

a key amendment to

Highlights the alteration as an important addition or change to a document or system.

FAQs

How can I use "a significant alteration of" in a sentence?

Use "a significant alteration of" to describe a major change or modification to something. For example, "The new regulations represent "a significant alteration of" existing policies".

What's the difference between "a significant alteration of" and "a minor adjustment to"?

"A significant alteration of" implies a substantial change, while "a minor adjustment to" suggests a small, less impactful change. The choice depends on the degree of change you wish to convey.

What can I say instead of "a significant alteration of"?

You can use alternatives like "a substantial modification of", "a major revision of", or "a drastic shift in" depending on the context.

Is it always necessary to quantify how "significant" an alteration is?

While not always necessary, providing context or details about the alteration can help the reader understand its importance. For example, instead of saying "there was "a significant alteration of" the data", specify what was altered and why it matters.