a severe alteration

USAGE SUMMARY

The phrase "a severe alteration" is correct and usable in written English.
It can be used to describe a significant or drastic change in something, such as a plan, document, or situation. Example: "The project faced a severe alteration after the unexpected budget cuts were announced."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

8 human-written examples

Distillation of the IL can be used to quickly obtain mixtures without any traces of coloration, but can leads to a severe alteration of the relative proportion of the constituents.

Electrochimica Acta

However, such a severe alteration of activity would be predicted to have far-reaching effects on Rab7-dependent pathways.

Human Molecular Genetics

Many researchers will be content to focus on the subset of candidates predicted to create a severe alteration in a protein sequence.

Genome Medicine

A lack of 2 to 4 teeth was not considered a severe alteration when the ram had similar BCS to the rest of the rams.

BMC Veterinary Research

However, despite the antiproliferative effect obtained by a severe alteration of SNO homeostasis, the inhibition of TrxR with auranofin in MCF-7 cells induced a pro-proliferative effect.

Breast Cancer Research

The mutation determines the deletion of the entire exon (131 bp) in the RNA processing, causing a severe alteration of the protein structure and thus the disease.

BMC Veterinary Research

Human-verified similar examples from authoritative sources

Similar Expressions

52 human-written examples

For example, a patient with severe alteration in mental status requiring intubation for airway protection should have improved mental status, require suctioning less than every 2 hours, be able to follow basic commands, and have a cough and gag reflex before extubation.

Critical Care

Overall, the interaction with acid fluids causes a severe mineralogical alteration of the cement and the development of a carbonated, low-porosity layer near the reservoir interface.

Journal of Hydrology

However, we cannot rule out other causes of mortality, for instance a severe hemodynamic alteration caused by the sudden increase in circulating tumor cells induced by CDDO-Im.

Plosone

Spink proteins are serine protease inhibitors involved in skin barrier formation: mutations in the Spink5 –LEKTI- gene in humans cause the Netherton syndrome, an ichthyosiform dermatosis (51); SpinKO KO mice have severe alteration in the Stratum Corneum (SC) [52] [54].

Plosone

Hyperkinetic patients exhibited the most severe alteration in afterload indices, and a worse outcome.

Annals of Intensive Care

Expert writing Tips

Best practice

When using "a severe alteration", ensure the context clearly indicates what is being altered and the consequences of that alteration. Providing specific details enhances clarity.

Common error

Avoid using "a severe alteration" when the change is minor or insignificant. Using it inappropriately can lead to exaggeration and weaken your message. Verify that the alteration is indeed substantial before using this phrase.

Linguistic Context

The phrase "a severe alteration" functions as a noun phrase, typically serving as the subject or object of a sentence. It describes a significant change or modification.

Expression frequency: Uncommon

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, "a severe alteration" is a grammatically correct noun phrase used to describe a significant or drastic change. As Ludwig AI indicates, it's commonly found in scientific and formal contexts. When employing this phrase, ensure the context clearly conveys the specific nature and consequences of the alteration. While effective for emphasizing substantial changes, avoid its usage for minor adjustments to prevent exaggeration. Consider alternatives like "a drastic modification" or "a major transformation" to suit specific contexts.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a drastic modification

Emphasizes the radical nature of the change, implying a significant departure from the original state.

a major transformation

Highlights the scale and impact of the change, suggesting a fundamental shift.

a significant deviation

Focuses on the extent to which something differs from a standard or expected norm.

a radical adjustment

Suggests a fundamental change made to align with new circumstances or requirements.

a substantial modification

Highlights the considerable extent of change and its broad impact.

a marked variation

Emphasizes a noticeable degree of change from an original state or condition.

a sweeping revision

Suggests an expansive and comprehensive change, indicating that almost everything has been altered.

a profound shift

Emphasizes that the alteration is deep and impactful.

a critical adjustment

Points out that the alteration is essential.

a considerable change

Highlights the importance of the alteration.

FAQs

How can I use "a severe alteration" in a sentence?

Use "a severe alteration" to describe a significant or drastic change. For example: "The experiment experienced "a severe alteration" due to unexpected contamination."

What phrases are similar to "a severe alteration"?

Alternatives include "a drastic modification", "a major transformation", or "a significant deviation", depending on the context.

Is it appropriate to use "a severe alteration" in formal writing?

Yes, "a severe alteration" is appropriate for formal writing, especially in scientific or technical contexts, where precise descriptions of changes are necessary.

What is the difference between "a severe alteration" and "a minor adjustment"?

"A severe alteration" implies a significant and substantial change, whereas "a minor adjustment" suggests a small and less impactful change. The choice depends on the magnitude of the change you are describing.