The phrase "a drastic modification" is correct and usable in written English.
It can be used when describing a significant or severe change made to something, such as a plan, design, or process.
Example: "The team decided that a drastic modification to the original proposal was necessary to meet the new requirements."
Alternatives: "a significant change" or "a major alteration."
This conclusion is supported by optical and electron miscroscopic investigation of the samples, which shows that for alloys containing little or no Pt, even with a high Au content, there is a drastic modification of the substrate by the formation of a thick anodic layer which is not sufficiently protective.
In conclusion, a significant proportion of the transcriptional responses seen during growth in urine were common for the three different strains examined, and the main differential regulation was observed among genes related to stress responses, energy metabolism, acquisition of trace metals, and a drastic modification of the cell envelope.
The combination of artemisinin and 3CA resulted in a drastic modification of artemisinin's activity (Table 3).
None of the primary cultures or lung cancer cell lines revealed such a drastic modification of signaling as a function of transformation.
However, it is also associated with a drastic modification of microbiota, which could be the cause of the enteroendocrine change [ 68, 69].
Again, it might be argued that a less drastic modification could be made.
On the other hand, if indeed the Cul3/BC-box interaction exists, the results for S. cerevisiae Cul3 might be interpreted as a recent, drastic modification of its ancestral function.
This review describes how minor ligand modifications can result in a drastic change in the metal metal interactions in multinuclear compounds.
Acid modification of clinoptilolite leads to a drastic change in its protolytic properties that can be quantified by measuring pH of its aqueous suspension.
"This is a drastic change".
However, a drastic change is in prospect.
