Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy.
Selective elimination of dysfunctional mitochondria by the autophagy pathway is termed mitophagy.
Selective elimination of PDGFRβ-dependent PI3K activation thus could be a potential therapeutic target for both atherosclerosis and Marfan syndrome.
Selective elimination of neural connections plays a major role in the establishment of mature circuits.
Selective elimination of TEMs in tumour-bearing mice impairs angiogenesis and slows tumour growth (De Palma et al, 2005).
Selective elimination of damaged mitochondria has been observed 82, 83, although the precise mechanisms are still incompletely understood 84.
A third hypothesis involves the selection of viable embryos through active selective elimination mechanisms that act to discard embryos with abnormal imprinting before mid-gestation.
It has been shown that parkin is selectively recruited to damaged mitochondria and is important in their selective elimination [ 70].
The general said that before the air strikes, the Serbs had conducted a systematic government-sponsored campaign of intimidation, repression and selective elimination of Kosovo Albanians.
This effect allows selective elimination of dislocations using in situ annealing.
However, due to the in-seam position of this band, selective elimination of this during mining is not practical.
