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Strategies for achieving specific and selective abrogation of E7 protein have been proposed as a rational therapeutic approach for HPV-positive carcinoma of the cervix [22].
Our findings suggest that the success of such anti-P2Y12 interventions relies on the selective abrogation of a platelet response autocrine activation of P2Y12 that is at least in part dependent on the local, high shear conditions.
The selective abrogation of BODIPY-SM domains by modulation of endogenous SM levels raised the possibility that the SM fluorescent derivative could reflect some natural large-scale compartmentation of endogenous SM [31].
The ability to accomplish selective abrogation of oncogenes by the use of intracellular sFvs opens a wide variety of possibilities in breast cancer investigation and therapy.
To confirm that this is selective abrogation of insulin-induced effects, we also investigated fetal bovine serum (FBS -induced HRE-Luc.
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Moreover, a positive correlation is seen with abrogation of excitotoxicity in response to selective excitatory amino acid receptor antagonists.
Experimental and selective ablation of outer and inner cells results in the abrogation of apoptosis in respective remaining neighbouring test cells.
Abrogation of this priming site impairs c-Jun transactivation and lead to selective inhibition of T91/T93 phosphorylation by various types of genotoxic stress, including UV radiation and anisomycin.
The N6-benzyl series 9a 9c also proved to be potent and selective A3AR agonists and the longer chain length linker 13 was tolerated at the A3AR without abrogation of affinity or selectivity.
Studies have identified selective induction of IDO in non-plasmacytoid DCs in the nasal lymph nodes, which is critical for inducing tolerance, for abrogation of IDO induction results in elimination of tolerance induction towards the inhaled antigen[ 53].
The abrogation of Art.
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