Sentence examples for with increasing affinity from inspiring English sources

It is seen from Eq. 2 that the value of ftb (1) increases with increasing target density, (2) decreases with increasing non-specific binding (Vu,brain), and (3) increases with increasing affinity to the target protein (Kd).

However, the difference in staining diminished with increasing affinity of the monomeric scFv.

Possible epithelial damage, due to viral infection, could promote the pathogenicity of PVL-producing strains with increasing affinity for collagen (I and IV) and laminin [ 23].

Our results show that this is indeed the case, where the decapeptides AEGPT AEEVD and AEGPT MEEVD were found to bind with increasing affinity (Kd=14.8±0.7 μM and Kd=4.2±0.5 μM respectively; Figures 5d and 5e) relative to the wild-type sequence decapeptide (Kd=28.9±3.1 μM; Figure 4c).

When we checked the receptor binding activities of one series of bisphenol derivatives (i.e., bisphenol E, BPA, bisphenol B, bisphenol AP, and bisphenol AF), we found this line-up to be the order of compounds with increasing affinity to ER-α.

It is reasonable to assume that the moderate performance of 7– 11 is linked to their exceptional affinities.[ 25] It is well understood that as binding strength increases, a point is reached where further enhancements are unproductive.[ 26, 27] However, one would normally expect that transport rates would start falling with increasing affinities, as anion release becomes rate determining.

Selections with labeled FQs resulted in several mutant antibodies with increased affinity or wider specificity toward different FQs.

Detection of fragments responsible for interaction with enzyme's binding site provides the basis for designing new molecules with increased affinity and selectivity.

Peptidomimetic analogs of the coactivator NR boxes inhibit competitively the interaction of the NR and coactivator, often with increased affinity for the NR relative to the native peptide.

Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.

Nevertheless, while local structural features of the interface were sometimes miscalculated, EGAD is globally successful in designing complexes with increased affinity.