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Passive immunization based on mAbs, however, may require a cocktail of mAbs with broader specificity to provide full protection, since mAbs are generally specific for single epitopes.
However, passive immunization based on mAbs may require a cocktail of mAbs with broader specificity in order to provide full protection since mAbs are generally specific for single epitopes.
We have produced an anti- Legionella single chain fragment with broader specificity towards Legionella serotypes than the parent monoclonal antibody.
The lower signal ratios for the remaining seven proteins suggest that they may represent RNA-binding proteins with broader specificity.
for further discussion of targets of Gcy1 and Pcs60), consistent with the protein microarray evidence that both proteins are RBPs with broader specificity.
Switching patients to second-generation drugs with broader specificity, such as dasatinib can overcome this resistance (Rosti et al, 2012).
Similar(51)
Generally, it remains to be determined whether small molecules are required to specifically target only one molecule to be clinically useful or whether, in a manner similar to medically relevant kinase inhibitors, molecules with broader specificities against subfamilies of enzymes might exhibit clinical efficacy.
Some LTPs with broad specificity are termed non-specific LTPs (nsLTPs).
Thus, the use of PCR tools with broad specificity in combination with species-specific tools is needed to address the issue of mixed Cryptosporidium infections.
To this purpose, the chemiluminescent assay was performed in the presence of orthovanadate (1 mM), a phosphatase inhibitor with broad specificity, or tetramisol (5 mM), a specific inhibitor of the TNAP enzyme.
Members of the subclass taxon Actinobacteridae (mostly actinomycetes) possess AGN-specific TyrA enzymes (light blue fill color in Fig. 2), but they separate into two distinct groups that correlate either with broad specificity for pyridine nucleotides (Actinobacteridae_1) or a NAD+-specific pattern (Actinobacteridae_2).
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