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Mammalian nucleotide excision repair (NER) eliminates the broadest diversity of bulky lesions from DNA with wide specificity.
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The VCBCT provides vaccinees with a durable local immunity with detectable levels of antitoxic and vibriocidal antibodies in the blood serum, as well as IgA coproantibodies with a wide specificity against a number of intestinal infections.
Cluster 3 is the largest of the six, with 11 members which are characterized by a wide specificity profile, with high activity on substrate 9 (methyl-3-hydroxy cinnamate) and lower activities to 6 (methyl-4-hydroxy cinnamate), 7 (methyl-3,4-dihydroxy cinnamate) and 10.
The azoreductases that have optimal activity at wide range of pH, temperature with wide substrate specificity could be potentially important in developing xenobiotic degradation technology.
All these results confirm that TolC of L. pneumophila Lens is a component part of a functional efflux pump with wide substrate specificity and driven by the proton motive force.
The L. pneumophila Lens tolC::kan mutant was sensitive to a variety of compounds including antibiotics and detergents, which supports the involvement of the TolC protein in a functional MDR machinery with wide substrate specificity.
However, in bioremediation processes enzymes with wide substrate specificity are desirable.
Furthermore, these enzymes might have a wide specificity spectrum.
Selections with labeled FQs resulted in several mutant antibodies with increased affinity or wider specificity toward different FQs.
The presence of orthologs to both a 2-keto acid decarboxylase and alcohol dehydrogenase with wide ranges of specificity in Cyanothece 7424, 8801, and 8802 provides annotation evidence for the hypothesized presence of non-fermentative higher alcohol pathways [ 12].
To this end, the LIPESV12_enzymes are therefore qualified as carboxylesterase EC 3.1.1.1 with wider substrate specificities.
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