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However, in contrast to our hypothesis, we found that females and males invest differently in immunity: males had higher baseline immunity than females, indicating immune maintenance, while immune system activation was higher in females than in males in response to a bacterial challenge, indicating immune deployment.

Thus, PfEMP1 are functionally selected for binding while immune selection acts to diversify the family.

While immune alterations persist at ICU discharge, there is, at cellular level, no persistent immune alterations among septic shock survivors analyzed 6 months after ICU discharge.

While immune sera contained high titer anti-VLP antibodies, the specific anti-gp41 antibody responses were low with no neutralizing antibodies detected.

It is concluded that HRs-antagonist play immune suppressive role through H1R, H2R and H4R while immune enhancing role through H3R.

Histological analyses were performed after H&E-, PAS- and Congo red-staining, while immune histochemistry was done for detection of CD3+ cells.

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Similar(21)

While immune-mediated CNS vascular permeability is a likely contributor to pathology in neurologic disease, the role of CD8 T cells in BBB breakdown under inflammatory conditions remains largely undefined.

While immune-mediated inflammatory myopathies are well documented in dogs, sIBM has not been described.

The cell division-related pathways have predominantly negative correlation with survival time, while immune-related pathways have predominantly positive correlation.

The inflammatory infiltrate in SS patients includes T and B cells, dendritic cells (DCs), and macrophages, while immune-mediated damage is believed to be driven by IC deposition, apoptosis, remodeling, and fibrosis [ 19].>> A number of recent reviews describe the current understanding of the pathogenesis of SS [ 11, 23– 25].

The hypothesis of regulatory cross-talks between immunity and digestion is also supported by the observation that in adult midguts a transcriptional switch occurs upon foodborne bacterial infection, whereby several digestive enzymes expression is silenced while immune-related gene expression is induced (Buchon et al., 2009b).

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