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Insulin stimulates glucose uptake by adipose tissue (AT) and muscle, whereas suppressing the release of glucose from the liver.

Suppressing CST1 resulted in a 20% reduction in invasion activity compared with control cells, whereas suppressing CST3 produced a slight increase.

Combining celastrol with drugs that place additional stress on homeostatic mechanisms (i.e., inhibition of HSPs) could exacerbate the response, whereas suppressing protein misfolding stress could protect cells from celastrol-mediated toxicity.

Interestingly, overexpression of Candidate 11 in C6 cells increased the cell proliferation, whereas suppressing the endogenous Candidate 11 by overexpressing a specific sponge RNA [ 38] reduced the cell proliferation.

Furthermore, expression of active β-catenin enhances self-renewal of Sca1+ cells, which have been identified as the primary mammary gland progenitor cells, whereas suppressing β-catenin decreases self-renewal of the Sca1+ cells (Chen et al., 2007).

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The drug also further increased ALDH3c whereas suppressed GSH content in BP-exposed FSL rats.

Second, the transcript levels of OsWRKY4 were activated by OsWRKY80-overexpression, whereas suppressed by OsWRKY80 RNAi, suggesting that OsWRKY4 may be a target gene of OsWRKY80.

These results demonstrated that PNS treatment led to enhanced angiogenesis in ischemic hearts whereas suppressed angiogenesis in growing tumor, implying a bidirectional regulatory action of PNS on angiogenesis in vivo depending upon the tissue type and pathological context.

H/R challenges induced the expression of Bax and cleaved caspase-3, whereas suppressed the expression of Bcl-2; however, the effect was diminished in cells transfected with AdshTRAF1 and was greatly increased by transfection with AdTRAF1.

Oryeongsan increased HG-inhibited membrane type-1 matrix metalloproteinase expression (MT1-MMP) and MMP-2 promotor activity, whereas suppressed HG-induced tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) expression.

Fair et al. reported that mitogen-stimulated T-cell proliferation was increased after oral gavage with DE-71 (a commercial penta BDE mixture) for 28 days in adult mice, whereas suppressed T lymphocyte multiplication was observed following BDE-209 exposure in rats during pregnancy and lactation.

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