volume of distribution

USAGE SUMMARY

The phrase "volume of distribution" is correct and usable in written English.
It is typically used in pharmacology to describe the distribution of a drug throughout the body's fluids and tissues relative to its concentration in the blood. Example: "The volume of distribution of the drug indicates how extensively it is distributed in the body compared to the plasma concentration."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

CHS however produced a higher volume of distribution (4-folds).

Acta Tropica

Therefore, the published models for volume of distribution, unbound volume of distribution and drug efficiency are also discussed.

Journal of Pharmaceutical and Biomedical Analysis

PET volume of distribution.

EJNMMI Research

volume of distribution.

EJNMMI Research

tissue volume of distribution.

EJNMMI Research

steady-state volume of distribution.

Annals of Intensive Care

Non-displaceable volume of distribution.

EJNMMI Research

VT = volume of distribution (mL.cm−3).

EJNMMI Research

representing the volume of distribution of water in tissue.

EJNMMI Research

Weight was included in the base model for clearance (CL) and volume of distribution (V).

Duke University

Remifentanil was found to have age-related changes in clearance and volume of distribution, but not half-life.

Duke University

Expert writing Tips

Best practice

When discussing drug pharmacokinetics, specify whether you are referring to the central, peripheral, or steady-state "volume of distribution" to provide clarity and avoid ambiguity.

Common error

Avoid assuming that "volume of distribution" represents a real physiological volume. It's a calculated parameter reflecting the extent of drug distribution relative to plasma concentration, not the actual physical space a drug occupies.

Linguistic Context

The phrase "volume of distribution" functions as a technical term in pharmacology and physiology. Ludwig shows it's used to describe how a substance, especially a drug, is distributed throughout the body's fluids and tissues relative to its concentration in the blood. This is a crucial concept in pharmacokinetics.

Expression frequency: Very common

Frequent in

Science

98%

Academia

1%

Wiki

1%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, "volume of distribution" is a critical pharmacokinetic parameter used extensively in scientific and medical fields. As Ludwig AI indicates, it is a grammatically correct and commonly used term that describes the extent of a drug's distribution throughout the body relative to its concentration in the blood. The analysis reveals that its primary usage is within formal scientific contexts, with authoritative sources like PubMed and ScienceDirect frequently employing the term. While alternative phrases such as “distribution volume” exist, understanding the precise meaning and implications of "volume of distribution" is essential for accurate dosage calculations and effective therapeutic interventions. Avoid misinterpreting it as a physical volume; rather, view it as a calculated parameter reflecting drug distribution characteristics.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

distribution volume

Reverses the order of the words while retaining the core meaning; slightly less common usage.

vd

Abbreviation for “volume of distribution”, commonly used in pharmacokinetic studies.

distribution space

Emphasizes the space in which a substance is distributed, rather than the quantity.

apparent volume of distribution

Highlights the fact that this volume is an estimate and may not reflect actual physiological spaces.

steady-state volume of distribution

Specifically refers to the volume of distribution when the drug concentration is at equilibrium.

tissue distribution volume

Focuses on the distribution within tissues, excluding other body compartments.

central volume of distribution

Refers to the volume of distribution in the central compartment (e.g., plasma).

peripheral volume of distribution

Refers to the volume of distribution in the peripheral compartments (e.g., tissues).

drug distribution volume

Explicitly specifies that the volume refers to the distribution of a drug.

extent of distribution

Describes the range or degree to which a substance spreads in the body.

FAQs

How is "volume of distribution" calculated?

The "volume of distribution" is calculated as the dose of the drug divided by the plasma concentration. It's a pharmacokinetic parameter that reflects how widely a drug distributes throughout the body.

What does a high "volume of distribution" indicate?

A high "volume of distribution" suggests that a drug distributes extensively into tissues and fluids outside of the plasma, potentially indicating lower plasma concentrations.

How does protein binding affect the "volume of distribution"?

High protein binding typically reduces the "volume of distribution" because the drug is largely confined to the plasma. Conversely, low protein binding allows for greater tissue distribution.

What's the clinical significance of the "volume of distribution"?

The "volume of distribution" is crucial for determining appropriate drug dosages. It helps predict the plasma concentration achieved for a given dose, influencing therapeutic efficacy and potential toxicity.