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The superfamily of GPCRs consists of a large number of related seven transmembrane proteins of highly varied function.
Gene duplication is classically discussed as leading to neofunctionalization (generation of new functions), subfunctionalization (generation of a varied function), or pseudogenization (loss of the gene and its function).
This varied function according to ErbB receptor expression and localisation may also go some way toward explaining the differential effect of HRGβ1 on the growth of the four breast cancer cell lines we observed in the present study.
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In addition, the available functional analyses of COG0523 members suggest varied functions and an interaction with various metals [ 15, 18, 45].
By mass spectrometry analysis we identified 64 proteins displaying varied functions.
Studies in vertebrates show that individual Smyd proteins control gene expression in order to fulfil varied functions during development.
Long noncoding (lnc) RNAs have varied functions including signaling, molecular decoys, scaffolding and guiding ribonucleoprotein complexes.
It has been suggested that SSRs in different gene positions may perform varied functions.
In mammals, Sin3 has two paralogues; Sin3A and Sin3B which are known to perform varied functions under different cellular conditions [ 4, 7].
Although the precise mechanism(s) await determination, S/MARs exhibit varied functions that include augmenting transcription (5, 10), insulating genic domains (11– 13) and facilitating replication (14, 15).
It is possible that Class II SDHs have evolved varied functions to meet the different environmental challenges faced by respective plants.
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