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In contrast, the first study on LGP2-deficient mice and cells infected with RNA viruses or challenged with synthetic dsRNA poly(I C), suggested a disparate function with LGP2 supporting signaling through MDA5 ligands but inhibiting RIG-I-mediated signaling [23].
Two mammalian isoforms have been identified, PLD1 and PLD2, with high sequence homology but disparate function.
The putative 781-amino acid protein has sequence homologies with a number of proteins of apparently disparate function and cellular localisation.
He showed that pleiotropy is widespread among expression traits and can occur among a large number of traits with disparate function, making its consideration essential in system genetics.
Therefore, these treatments, especially RP, appear to have much different effects on the proteome and physiology depending on the tissue type, with heart and liver perhaps lying at extremes, considering their disparate function and energetics.
A neighbour-joining phylogenetic tree of protein sequences for the SLC30A family shows that human and mouse SLC30A9 diverge from the rest of the family, possibly indicating a disparate function for this family member.
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The last functional group (Table 1, functional group VI) contains a group of 12 genes with disparate functions.
The report's biggest package of recommendations is to overhaul the intelligence operations, calling for a cabinet-level national intelligence director within the White House who would control the budgets of all 15 federal intelligence agencies to unify and better coordinate their disparate functions.
Because genetic programs can be conceptualized as networks of genes for a wide range of systems, the discussed models can be successfully applied to implement disparate functions.
Current federal programs and offices that address education, health, and safety of students are too often disparate, functioning in isolation, too frequently addressing the same students but via a myriad of steps, hoops and with different -- sometimes contrary - goals.
These results show that laminin α1LG domains and consequently their receptors have disparate functions in the neuromuscular system.
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