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Exact(57)
Thus SpdS may be considered a genetically validated drug target in African trypanosomes, but chemical validation will have to await the development of inhibitors that selectively and irreversibly inactivate the enzyme.
For instance, in the top 1 %, the method identified 2 validated drug targets.
In the future, we need to know which are the most important validated drug targets".
In this analysis, validated drug targets for currently existing drugs and essential non- homologous proteins were taken to assess the performance of the method.
Finally, the crystal structure of PyrG was solved, paving the way for rational drug design with this newly validated drug target.
The presence of metabolites validated drug use in the 2 3 days prior to the test.
It is important to realize that the LOPAC set already have validated drug activities and many are clinically used for this purpose.
The aaRSs have been already recognized as validated drug targets.
Similar(3)
Further drug interactions were obtained from the commercial database ABDA that is based on approved and validated drug-related data in comparison to DrugBank.
We conducted druggability analysis of the proteins corresponding to genes in our predicted ovarian GRN using CancerResource [ 56], a comprehensive knowledgebase of experimentally validated drug-target relationships.
A commercial, pharmaceutical database such as ABDA, which contains approved and validated drug-related data, can ensure better data quality and more comprehensive knowledge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com