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Caregivers were excluded if their child had a history of acute life-threatening events due to manifestations of GERD or a severe unstable illness that could exacerbate caregiver burden.
Residents with a terminal or unstable illness, significant advanced cognitive decline (Mini Mental State Examination 17 ≤15), or physical symptoms that preclude the safe use of exercise equipment in a group setting (eg, Parkinson's Disease or hemiplegia) will be ineligible.
The severity of their symptoms was matched by more unstable illness conditions, which needed more frequent and vigilant monitoring while the symptoms were resistant to treatments and other self-management techniques.
Also, the protocol of the original study excluded patients with serious or unstable illness; thus, some patients seen in clinical practice with hypertension, type 2 diabetes mellitus, and cerebrovascular or cardiovascular disease may be more ill than those studied in this post hoc analysis.
Similar(54)
Subjects in the two double-blind studies were eligible for the open-label study if they had completed at least 24 days of previous double-blind treatment or discontinued because of tolerability issues, if they were expected to benefit from continuation of treatment, and if they had no other serious, unstable illnesses and were otherwise physically healthy.
There was no difference in the proportion of people with a chronic unstable medical illness.
Patients with very serious, unstable physical illness and other medical conditions or histories contraindicating use of study drugs were excluded.
Consumers who were not mentally competent (assessed by a score of < 6 on the Abbreviated Mental Test) [ 24], had an unstable mental illness, or did not understand the English language sufficiently were excluded.
Subjects were disqualified if they were pregnant or lactating; had clinically serious unstable medical illness; were receiving other medications; had a history of psychosis, mania or severe major depression; reported concurrent dependency to alcohol, cocaine or hallucinogens; had a history of antisocial personality; or were mentally retarded.
GPs are asked to exclude patients if they have signs of red flags, acute LBP of less than 3-4 weeks, those already under secondary care, had recent lumbar spine surgery, LBP as part of a presentation of multiple body pains e.g. fibromyalgia, thoracic or cervical pain and unstable psychiatric illness.
Exclusion criteria for all participants included contraindications for MRI or TMS, severe visual impairment, history of alcohol/substance misuse, use of benzodiazepine or anticonvulsant medication, past neurological or psychiatric history (apart from dementia), focal brain lesions on brain imaging or the presence of other severe or unstable medical illness.
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