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She always started seated in peaceful lotus pose like the others, yet somewhere between sun salutation A and B, an unknown trigger set her off.
As gas spirals toward the neutron star, it spins faster and faster until some unknown trigger produces powerful, coherent radio beacons.
This indicates that an unknown trigger may lead to the upregulation of SETDB1.
Instead, it is activated through autophosphorylation induced by a currently unknown trigger [ 6] and potentially through phosphorylation by cyclin-dependent kinases (CDKs) and mitogen-activated protein (MAP) kinases [ 7].
Following rapid virus evolution and in the presence of an unknown trigger, the novel SARS-CoV may have effectively adapted to the human host, as illustrated by a second pattern characterized by a higher human-to-animal virus antibody titer in infected persons.
RA is an autoimmune disease in which an as yet unknown trigger results in a chronic inflammatory process affecting the synovial membrane of the joints (Gabriel 2001), while OA is often thought to result from natural aging processes on the joint surfaces (Sharma et al. 2006).
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The HELLP syndrome is generally considered the clinical extreme of preeclampsia, although its acute onset and frequent spontaneous (albeit temporary) resolution within days, even in those women who do not deliver [41], [42], suggests a more rapid deterioration initiated by temporally released, yet unknown triggers.
This raises a tantalizing thought: unknown triggers may have a role in the pathogenesis of HLH.
Genetic and environmental factors together with unknown triggers (infections and so on) may directly lead to initiation of RA.
In type 1 diabetes, as a result of as yet unknown triggering events, auto-aggressive CD8+ T cells, together with a significant number of other inflammatory cells, including CD8+ T lymphocytes with unknown specificity, infiltrate the pancreas, leading to insulitis and destruction of the insulin-producing beta cells.
The most likely implication of the HLA associations is that the susceptible person's T-cell repertoire contains CD8+ T cells that can recognize peptides derived from proteins in a still unknown triggering or target cell, which we will arbitrarily designate a fibrocartilage cell.
Related(20)
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Justyna Jupowicz-Kozak
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