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Stress is a well known trigger factor for migraine [1].
TNF-α is a well known trigger of acute inflammatory response during mycobacterial infection and largely secreted by activated macrophages [57], [58].
Indoxyl sulfate induces oxidative stress [ 42, 43], a well known trigger of eryptosis [ 9, 12].
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This autoimmune disease is regarded as a multifactorial trait involving environmental factors such as intake of certain drugs, psychosocial stress, smoking, or climate conditions, all of which are well known triggering factors for primary manifestations or exacerbation in susceptible individuals [2].
Well known triggers include increased levels of ROS and increased Ca2+[ 5].
As viruses are well known triggers of wheeze and a potential confounder of the association between bacteria and wheeze, we controlled for viruses in bacteria samples and bacteria in virus samples by including both in the multivariate analyses.
Similarly, beer is well known to trigger recurrent gout attacks, often occurring within 24 hours after alcohol consumption [ 7].
Nitric oxide is well known as a trigger for macrophage apoptosis [ 45].
It is well known that TCR triggering promptly induces F-actin polymerization via activation of signaling pathways involving PTKs, PI3-K, Vav, Rac and Abi/Wave complex which are also known to play a role in integrin activation [15], [16], [17].
It is well known that seizures can trigger secondary headache attacks as well (postictal headache, ICHD-II 7.6.2) [4, 5].
It is well known that leucocyte activation triggers the release of various pro-inflammatory agents.
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