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Hence, some researchers (e.g. Shiferaw et al. 2010) further propose that the combined use of participatory appraisal and conventional methods may be essential for an ultimate disease control strategy.

Thus, IFG treatment slowed disease progression, but did not change the ultimate disease outcome.

From prospective studies evidence has accumulated that increased levels of C3 and CRP can predict T2DM and coronary events and could be candidate biomarkers for a pathological state preceding the ultimate disease [3], [8], [26], [27].

Australasian and Canadian studies were combined in a prospective meta-analysis for the primary outcome of survival and also time to ultimate disease progression (time from randomisation until first evidence of progression after chemotherapy).

Herein, we present a series of three 'proof of concept' field studies and one laboratory study that utilize a combination of novel approaches to explore the range of microparasites potentially impacting wild salmon populations and the cumulative impacts of genetics, temperature stress and predators on the diversity and loads of microparasites and ultimate disease outcomes.

It has been proposed that PSA bounces are probably the result of some mechanism compromising membrane integrity (i.e. radiation-induced prostatitis) in PSA-producing epithelium.[ 24, 25 ] The magnitude of the bounce is rarely >1.0 ng/ml and there does not appear to be any clinical significance in terms of ultimate disease control.

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It is possible that differences in the background complotype (33) of an individual may determine the ultimate clinical disease process.

Is disease-associated epigenetic variation a proximate or an ultimate cause of disease?

Death is the ultimate consequence of disease progression and thus reduced mortality and improved survival describe an impact on disease progression.

"To think is to add a flame to fire," wrote Balzac, mental activity being in his view an "instrument of destruction that deteriorates our nerves and is the cause of our illnesses and death".Whatever the ultimate cause, heart disease and gangrene got the better of Balzac.

Functional annotation results can have a strong influence on the ultimate conclusions of disease studies.

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