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In Canada, a trial has been started that compares induction of labour to expectant management in women with PPROM.
Recently, a randomized multi center trial comparing the laparoscopic with the open approach in early stage endometrial cancer called the LACE trial, has been started in Australia.
This is relevant since small molecular inhibitors have been developed and a phase I trial has been started (http://epizyme.com/programs/dot1l.asp).asp
A large-scale trial has been started in the United Kingdom with the aim of evaluating the effectiveness of different methods for the early detection of breast cancer.
Another trial has been started with high-loading dose of atorvastatin (80 mg); in this small study the results show a benefit for patients receiving the high-loading dose compared to placebo (CIN: 5% versus 13.2%, P = 0.046) [ 68].
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Recently, two clinical trials have been started with genetically modified, IL-12-secreting lymphocytes.
Due to the higher tumour uptake and favourable excretion route, clinical trials have been started on the Demobesin 4 compound.
These gene therapy studies were initiated in 2005, and till 2013, six clinical trials have been started, according to the ClinicalTrials.gov database.
Currently two large prospective trials have been started to address the predictive performance of two gene expression signatures in early breast cancer (Bogaerts et al, 2006; Sparano, 2006).
At least two to three further, large, randomized trials have been started, including the ongoing Normoglycemia in Intensive Care Evaluation (NICE -Survival UsiNICE -Survivalorithm RegUsingon (SUGlucoseudies [ 5], Algorithmiscontinued Efficacy of Volume Substitution and Insulin TheRegulationvere SUGARstudiesP) study [ 6].
A controlled trial with abatacept in pSS has been started in the authors' department, but results of treatment with abatacept in pSS are not yet available.
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