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This trial has been performed to estimate the production of methane with a sugar-rich forage versus a high-fibre grass.
Although the preliminary evidence is encouraging, Assimes cautions against prescribing cilostazol simply based on the association, and suggests waiting until a rigorous clinical trial has been performed to test out the drug's functionality when it comes to treating heart disease.
To date, only one randomised and controlled prospective trial has been performed in the UK.
A clinical benefit of leukoreduction is still somewhat controversial, particularly in the critically ill patient where no randomized, controlled trial has been performed [70].
Once such a trial has been performed, further studies can be done in patients undergoing severe alcohol withdrawal to help precisely define the indications, dosing schedule, and timing for this promising therapy.
Despite the intent to provide a practical, simple and versatile radiolabelling method, there has been a large variation in labelling efficiencies reported in the literature, likely due to variations in protein/peptide properties and labelling conditions (see Additional file 1: Table S1), and no clinical trial has been performed to date with proteins labelled using the tricarbonyl labelling method.
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Previously, no large comparative trial had been performed.
Several subgroup analyses of the PROWESS trial have been performed based on clinical and biochemically relevant baseline variables.
Some analysis of subgroups of CKD patients in larger randomised controlled trials has been performed and has proved valuable.
Many trials have been performed to investigate the role of intra-articular injection of HA in alleviating the symptoms in hip osteoarthritis.
Human clinical trials have been performed with patients for cancer, cardiovascular disease and metabolic diseases.
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