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Exact(6)
Access to contraception must be continuous, motivation to contracept must be sustained, and side effects such as changes to the menstrual cycle must be tolerated over time.
The question obviously arises as to how this would be tolerated over time.
Rituximab has remained generally well tolerated over time and over multiple courses, with a safety profile consistent with published data of patients with moderate-to-severe RA.
8 11 13–16 Long-term follow-up of patients in these trials indicated that rituximab remained well tolerated over time and multiple courses.
This analysis demonstrates that rituximab remains generally well tolerated over time and multiple courses, with a safety profile consistent with published data and clinical trial experience.
These lesions and the extra work they impose on the RV can be variably well tolerated over time, and often become fairly advanced before the onset of symptoms, but regardless of the clinical manifestations and pathophysiologic timeline, they are detrimental to the RV, and ultimately to the patient.
Similar(54)
Although incompletely understood, substitution data point to the critical nature of Duox functions, since changes in the Duox sequence are also poorly tolerated over evolutionary time.
"The recruitment of terrorists in fact is easier in situations where rights are trampled upon and injustices tolerated over a long period of time," he said.
Autologous pigment epithelial cells transplanted to the subretinal space in neovascular AMD patients [ 28, 29] were well tolerated over a long period of time.
22, 23, 25 Palonosetron at 3 times the approved dose was well tolerated over repeated cycles with no unexpected adverse events.
Given that OA pain may require treatment over extended periods of time, these findings demonstrating that lumiracoxib is efficacious and well tolerated over 1 year are important.
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