Sentence examples for through impairment from inspiring English sources

Our results clearly suggested that PP2A inhibition impaired net glycogen synthesis through impairment of GS activity and glycogen synthesis as well as stimulation of phosphorylase activity and glycogen breakdown.

Hazard quotients, applied as a preliminary evaluation, indicated that PBDEs may pose a moderate hazard to ospreys and peregrine falcons through impairment of reproductive performance.

Therefore, mitochondrial cholesterol loading may have an important role in cancer cell survival by a dual effect through impairment in mitochondrial function and dynamics, while promoting HIF1α stabilization via depletion of cytosolic 2-OG levels and generation of mitochondrial ROS.

Interestingly, studies have shown that pristine graphene or GO, as well as polyethylene glycol (PEG -modified GO (PEG -modifiedit breast cancer cell miGOation through impairment of oxidative phosphorylatinhibit mitochondrial respiration [44, 45].

These results suggest that pain-related phenotypes after gastrointestinal surgery are enhanced in carriers of the minor G allele of the rs3845446 SNP, possibly through impairment of Cav2.3 VACC function that is responsible for the activation of visceral inflammatory pain stimulus-elicited antinociception.

RAD23 is implicated in DNA repair and is known to interact with the E3 ligase E6AP, suggesting that its degradation by ubiquitylation may contribute to tumor progression through impairment of the DNA repair process.

The direct channel works through impairments of cognitive ability due to early-life malnutrition that harms school success and, subsequently, labor market outcomes.

In addition to direct effects, some of the impact of these factors was mediated through impairments in people's ability to function in their normal role and social environment.

It is clear that exposure to arsenic during pregnancy is having a significant effect on intrauterine growth, which may predispose infants to chronic lung diseases through impairments in lung growth and development.

This suggests that different pathologies can produce similar cognitive impairments through damage to the same tracts.

Therefore, lethality in mutant SPS1 flies is probably being induced through the impairment of this major role, and not through its effect on selenoprotein biosynthesis.