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Upon binding to cAMP, the regulatory subunits are released from the catalytic subunits, and thereby activated.

The PTIO presumably depolarized B31/B32, and thereby activated the K+ currents, which repolarized B31/B32.

In the 1980s, it was shown that CY depleted cycling suppressor T cells, now known as regulatory T cells, and thereby activated anti-tumor CD8 T cells [24].

For instance, TGF-α and IL-8 are processed and thereby activated by meprin α during inflammatory disease in human lung [12].

Bid is processed and thereby activated by caspase-8 in many cell types and systems.

In our molecular study, miR-125b inhibited AhRR and thereby activated AhR, leading to the induction of mdm2.

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Several ligands including the growth factor pleiotrophin (PTN) bind to RPTPβ and inhibit its phosphatase activity, thereby activating cellular signalling pathways.

Hyperactivation of PARP-1 depleted ATP pools in dopaminergic (DA) neurons, thereby activating AMP-activated protein kinase (AMPK).

This inactivates sororin and thereby activates the releasing activity that triggers cohesin's dissociation from chromosomes.

Trib3 inhibits Akt activity and thereby activates FOXO3a, which in turn binds to and activates the trib3 promoter.

Thought to be important for cell-signaling activity, this surface is made accessible by proteolytic cleavage, thereby activating the cell-signaling function of these enzymes.

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