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Exact(4)

A potential advantage of CTC over OC and FS is that laxative components of the bowel preparation can be reduced or even eliminated, decreasing test burden [ 7].

As it is unclear how patients trade off health gains against test burden, represented by test type and frequency, we did not impose functional restrictions on this.

This study furthermore indicates the importance of research into the effectiveness of endoscopic surveillance for patients with BE, and into reducing the test burden, for example by optimising the test-frequency based on clinical characteristics.

However, the decision to participate or not in any screening programme is preferably based on an individual decision-making process of weighting the test burden against the potential benefits of screening.

Similar(55)

While all new vectors will require extensive preclinical testing to validate safety and performance prior to clinical use, regulatory testing burden for follow-on products can be reduced by combining carefully designed synthetic genes with existing validated vector backbones.

While kernel density estimation methods produce stable and geographically detailed patterns of the late testing burden, the resulting pattern depends critically on the definition of the at-risk population.

Note that testing ratios between two metabolites a and b is independent of their order, as log(a/b) = −log(b/a), which halves multiple testing burden.

Pe'er et al. [3] estimate a multiple testing burden of approximately one million tests for genome-wide association analyses in European samples.

If a gene spans multiple regions of linkage disequilibrium, then the latter choice is preferable because it requires less genotyping and induces a smaller statistical testing burden.

Here, by specifically examining those single-SNPs which had main effects which did not replicate for pairwise interactions the multiple testing burden is further reduced.

Marchini et al. [23] have shown that, even considering a conservative multiple testing burden, strategies which explicitly examine interactions often have greater power to detect associations when the underlying model includes interactions as this approach can model the true genetic effect and Evans et al. [24] have examined the power of two-stage approaches to detect epistatic interactions.

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