Sentence examples for genetic burden from inspiring English sources

Dr. Goldstein argues that the genetic burden of common diseases must be mostly carried by large numbers of rare variants.

Recent and rapid human population growth has led to an excess of rare genetic variants that are expected to contribute to an individual's genetic burden of disease risk.

The children of those rapes, who are now becoming adults, who have born their genetic burden like a disgrace.

For mutation accumulation, purging of the genetic burden may be more effective than hitherto suspected, suggesting a diminished role of mutation accumulation in determining mortality late in life.

Compensatory mutations typically occur under drug selection to minimize the biological cost of acquiring the resistance mutation, and the resulting balanced genome minimizes the genetic burden of resistance [16].

Because relatively younger CAD cases (who may have a higher genetic burden than older cases) were compared with older controls, one cannot exclude the possibility that the benefits of carrying the 279F allele may have been over-estimated here.

These data verified that an individual with del2q37 syndrome carried other genetic burdens in his genome.

Also, given that such environmental factors as diet, activity level, stress, smoking and air quality are known to be important determinants of CAD risk, the first line of cost-effective and safe intervention for an individual with a high genetic risk burden would include modulation of such environmental factors instead of more costly, high-tech approaches, such as gene-based biological therapies.

Thus, we examined the associations among genetic risk, illness burden, lithium treatment, and brain structure in BD.

Because sexual reproduction mixes and reshuffles genomes, some offspring might escape with few or none of the genetic errors that burden their parents.

After accounting for confounding factors such as mouse genetic background, parasite burden, and disease state (e.g., moribund vs. non-moribund and susceptibility vs. resistance to ECM), we found that more than 200 host genes, based on their transcriptional alterations, were associated with the pathogenic events occurring during ECM [11].