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Two important observations suggest TLR2 as a novel target to consider for therapeutic intervention in atherosclerosis.
Infections appeared to be a frequent complication leading to death, suggesting that infections are an important target to consider for reducing mortality in dialysis populations.
Given the role of T cells in atherosclerosis, they may be an important target to consider when developing therapies to treat SLE and CVD.
While CVD remains an important issue among dialysis patients, infections appear to be an important target to consider as a means to reducing mortality in that population.
Our data predict hyaluronidase synergism with cytotoxic agents and demonstrate a significant survival benefit with combination therapy, providing HA as a novel stromal therapeutic target to consider for patients with pancreatic cancer.
Since TGF-β plays a critical role in mucosal tissues in the formation of tissue-resident memory CD8 T cells (Mackay et al., 2013; Zhang and Bevan, 2013), IgA-producing B cells (Cazac and Roes, 2000; Borsutzky et al., 2004), and as revealed here Tfh cells, it is an attractive target to consider in the development of a broadly protective universal influenza vaccine.
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Recently, many new structures have been studied by structure genomics initiatives, delivering a wealth of targets to consider.
The distribution and storage efficiency together with the environmental sustainability are mandatory targets to consider when designing and managing modern supply chain (SC) networks.
Bacteria are important ecological nanotoxicology targets to consider when assessing MNM safety: bacteria are exposed to MNMs in water, sewage, soils, and sediments, wherein they influence MNM fates; bacteria can also be impacted — with potential health and ecosystem consequences.
Other potential C. parvum kinase targets to consider include those where there is precedence for preferential inhibition of the parasite kinase (including P. falciparum and T. gondii) over the human orthologue.
Recent data also suggest that kallikreins may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion, and, thus, may represent attractive drug targets to consider for therapeutic intervention [ 50].
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