target proof

USAGE SUMMARY

The phrase "target proof" is not standard in written English and may cause confusion.
It could be used in contexts related to security or protection, but it is not widely recognized. Example: "The new design is target proof, ensuring that it can withstand various forms of attack."

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

2 human-written examples

According to these schools, a doctor remembers that, in earlier cases, symptom A was alleviated by medication B. They do not infer that medication B makes symptom A disappear, or that the illness C is the cause of symptom A. Second, the Five Modes do not exclusively target proof.

SEP

Use of PD biomarkers in early clinical trials extends hypothesis testing and confirms whether a drug hits a tumour target (proof of mechanism, POM) and thereafter, the anticipated tumour outcome is reached (proof of concept, POC).

British Journal of Cancer

Human-verified similar examples from authoritative sources

Similar Expressions

58 human-written examples

Due to the cancer heterogeneity, different tumor models will be needed according to the development stages: target validation, proof of concept of target inhibition by a lead compound (small molecules or biotherapeutics), or candidate selection for further clinical development.

Bulletin du Cancer

Many native peoples became prey of European countries, companies, and colonies, and of Americans, whose bounty proclamations set targets, proof of "Indian kill" and prices.

The Guardian - Opinion

Clinically, target occupancy can be used to unequivocally confirm "drug-on-target" (proof of mechanism), (Morgan et al. 2012) guide clinical dose selections, and enable data-driven clinical "Go/No Go" decisions depending on whether the onset of side effects occurs prior to or after desired target occupancy range for efficacy (Wong et al. 2009).

EJNMMI Radiopharmacy and Chemistry

Notwithstanding these difficulties, murine models can represent useful tools for target validation and proof-of-concept studies for novel tumour-specific antigens.

British Journal of Cancer

The sex hierarchy is an excellent target for proof of principle studies, with relatively few genes in the core pathway (n = 12) and there is extensive knowledge about the relationships among these genes.

BMC Systems Biology

The selection of targets is proof of the policy to which I have referred.

The Guardian

Two areas of application were targeted as proof of principle: (A) selective product recovery in nanocompartments and (B) enzymatic conversion in nanocompartments.

Journal of Biotechnology

We searched for gene expression changes affecting key cell signalling pathways that may be targeted as proof of principle in a CRPC in vitro cell line model.

European Urology

In addition, the results of Dll RNAi in D. pulex [ 6] provide possible comparative data regarding phenotype, which is why this endogenous developmental gene was selected as a target for proof-of-principle TALEN in D. pulex.

BMC Biotechnology

Expert writing Tips

Best practice

When using "target proof" in technical writing, ensure the context clearly defines what aspect of the target is being proven or validated. For example, "target proof of mechanism" in drug development.

Common error

Don't assume "target proof" implies invulnerability. It often refers to providing evidence related to a specific target, not necessarily making it invulnerable. Instead of saying "the system is target proof", clarify what aspect has been validated or proven.

Linguistic Context

The phrase "target proof" functions primarily as a noun phrase or adjective phrase. It suggests providing evidence or validation related to a specific "target". This usage appears predominantly in scientific and technical contexts, as shown by Ludwig.

Expression frequency: Rare

Frequent in

Science

60%

News & Media

20%

Formal & Business

10%

Less common in

Encyclopedias

5%

Wiki

2%

Reference

3%

Ludwig's WRAP-UP

In summary, "target proof" is a relatively uncommon phrase that implies providing evidence or validation related to a specific target, predominantly within scientific and technical fields. While not grammatically incorrect, it's important to ensure clarity and precision when using the phrase. As Ludwig suggests, this expression indicates the act of providing sufficient evidence to support claims made about targets. When in doubt, consider using alternative phrases like "proof of concept" or "target validation" for better clarity and broader understanding.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

proof of concept

Focuses on confirming the feasibility of a concept or idea.

target confirmation

Emphasizes confirming the target's identity, relevance or success.

validated target

Highlights that the target has been validated and verified.

target validation

Focuses on confirming the accuracy and reliability of a target.

target verification

Highlights the verification of a target to ensure validity.

goal validation

Emphasizes confirming the goals have been correctly set.

objective evidence

Highlights the presentation of unbiased information for confirmation.

target substantiation

Focuses on providing evidence that supports a target's claim or characteristic.

foolproof target

Indicates a target that is simple and cannot fail.

bulletproof target

Suggests a target that is extremely resilient or resistant to failure.

FAQs

How can I use "target proof" in a sentence?

While "target proof" isn't a standard phrase, you might use it to describe something providing evidence about a target. For example, "The biomarker serves as "proof of target engagement" in the clinical trial".

What does "target proof of mechanism" mean?

"Target proof of mechanism" refers to demonstrating that a drug or therapy is interacting with its intended biological target in a way that produces the desired effect. It's a key step in drug development to "validate target engagement".

Which phrases are similar to "target proof"?

Similar phrases include "proof of concept", "target validation", and "objective evidence", depending on the specific context. Consider which phrase best captures the intended meaning.

Is "target proof" commonly used in everyday language?

No, "target proof" is not commonly used in everyday language. It's more likely to appear in specialized fields like scientific research or technical documentation. Therefore, use "precise language".