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To ensure rational targeted therapy, target validation of compounds should be carried out with multiple reliable and unbiased methods.
Issues discussed included optimal trial design for targeted therapeutics, together with target validation in early studies.
This enormously valuable analysis should also help further validate these animal models for drug target validation purposes.
Industry cared about "target validation," for instance — affirming the impact of a molecule on a disease — which was a low priority for most academic researchers.
I'm working in the target validation group.
Target validation is a crucial element of drug discovery.
Pharmacogenomics is pertinent to all phases from drug target validation to final approval for clinical use.
Details as follows: (1) Conduct exploratory work that includes project conception, target validation and screening.
Therefore, early target validation and assessment without a large up front investment is becoming critical.
The role of ANNs in target validation is discussed, including their capabilities and limitations.
Examples of the uses of ANNs in target discovery, target validation, and hit evaluation are given.
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