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Our model provides the supplier and the customer increased flexibility in achieving target availability.
The engineering challenges are to achieve long-term target availability while minimizing radiation exposure to workers and to the environment.
The method of choice for defining this relationship is the use of a well-understood probe (or radioligand) which allows the quantification of target availability at baseline and following the administration of various doses of a novel drug.
In the field of after sales service logistics for capital goods, generally, METRIC type methods are used to decide where to stock spare parts in a multi-echelon repair network such that a target availability of the capital goods is achieved.
Target availability also affects miRNA release from Argonaute, which may be triggered by Aβ, resulting in subsequent degradation [49].
These results suggest that target availability can stabilize the association of a miRNA with Argonaute and protect the miRNA from degradation.
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We investigated whether EGCG and IIF, administered individually and in combination, could vary the expression of their molecular targets LR67 (EGCG) and RXRs (IIF), respectively, and whether the resulting cytotoxicity could be assigned to increase in molecular targets availability.
By contrast, in infection with CCR5-tropic viruses, it is unclear which CD4+ T cell population is ideal to study in order to understand target cell availability [23].
However, the level of central memory CD4+ T cell destruction was essentially identical in early infection, indicating that target cell availability of ability to infect/destroy these cells was not likely a factor in early infection or the outcome.
While chemokines may block viral entry by binding to CCR5 and contribute to endogenous anti-HIV activity, increases in their expression may paradoxically facilitate infection by increasing target cell availability.
The association of HSV-2 with higher susceptibility to HIV-1 infection may be attributable to higher CD4+ T cell counts in circulation and in turn with higher target cell availability for HIV-1 in sites of entry.
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Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com