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Experimental data show that zwitterionic lipid headgroups take part in the interaction with Penetratin suggesting that the external leaflet lipids of cells plasma membrane are competent for peptide interaction in the absence of net negative charges.
Though two domains (D1 and D2) take part in the interaction between LILR and HLAIs, previous studies [28], [29] and the co-crystal structures of HLA-A*0201 HLA-A*02011 [10] and HLA-G1 with LILRB1 [30] indicand that the main contacts (nearly 75% of them) are contributed by the first domain, D1.
The question of whether macrophages take part in the interaction of NP cells with Fas ligand and consequently contribute to clearance of apoptotic cells, however, remains open.
It is unclear at present whether the REJ domain itself can take part in the interaction with the egg glycoprotein coat The REJ domain has the potential role in regulating the ion channel which triggers the acrosome reaction [ 81, 83].
The autistic person is not ignoring other people; she may be struggling to take part in the interaction at all.
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The understanding of a particular process at the most basic level thus involves identifying those substances, among thousands present in a cell, that take part in the interactions.
Furthermore, only the fraction of the expressed protein taking part in the interaction is visible, making the determination of the intracellular site of binding more precise.
To further identify the residues taking part in the interaction, we have calculated the accessible surface area (ASA) of the amino acid residues.
The analysis of the residues taking part in the interactions in the ten selected ligplot molecules and the residues involved in the binding of natural substrate with the cysteine synthase revealed that certain amino acid residues are found to be conserved in most of the analyzed interactions (Table 3).
Together all these evidences suggest that the PE domain, which helps in secretion or stabilization of the interacting proteins, is perhaps per-se a weak antigen and does not take part in the host-pathogen interaction.
Re component was probably in rhenium oxide state rather than Re0 metal state to take part in the reaction via interaction with Ru0 metal.
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