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Exact(20)
This system makes it possible to identify any subtle deficiencies in systemic cell function which may underpin some of the clinical characteristics of this disorder.
As a proof of concept, we have chosen a very aggressive mammary adenocarcinoma model (TSA-Luc cells), which forms lung metastases upon systemic cell injection.
Engineering of cell-based constructs for treating a variety of immune-related diseases by local transplantation of the cells in a pre-designed matrix is an emerging therapeutic approach, which can potentially reduce the side effects associated with systemic cell injection.
Given that cell rolling is a pre-requisite to firm adhesion for systemic cell homing, we examined the potential of immobilizing sialyl Lewis X (SLeX) on mesenchymal stem cells (MSCs) to induce cell rolling on a P-selectin surface, under dynamic flow conditions.
Although chemokines direct both local and systemic cell migration, interruption of inherent chemokine responses in the donor tissue unexpectedly had a greater therapeutic impact on allograft vasculopathy.
These results demonstrate that the MPD-like phenotype observed in N1N2K5 and RBP-JK5 mice is caused by systemic cell non-autonomous effects due to loss of Notch signaling in the skin.
Similar(40)
In contrast to the innate immune system, the adaptive immune system is composed of highly specialized systemic cells and defensive processes that are capable of preventing, or at least restricting, specific pathogen invasion.
First, Dr Lakshmi Krishnan presented on archaeosomes which are an archaeal liposomal delivery system with potent adjuvant activity for induction of systemic cell-mediated immunity including CD8+ T cell responses.
We have confirmed a distinct scavenger response after exposure to systemic cell-free hemoglobin.
Postnatal day 6 (P6) rat pups were exposed to a combined insult of (1) systemic cell-free Hb or vehicle solution administered intraperitoneally (i.p).
In particular, we previously reported a significant suppression of the systemic cell-mediated response toward wheat gliadin in DQ8 transgenic mice receiving nasally a recombinant α-gliadin.
Related(20)
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structural cell
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systemic approach
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systemic Risk
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