Sentence examples for system notch from inspiring English sources

In the developing nervous system, Notch signaling plays fundamental roles in neuronal progenitor maintenance and the decision between neuronal and glial lineages.

This finding is consistent with other studies, reporting that in the vertebrate peripheral nervous system Notch signals promote proliferation at the expense of differentiation of neuronal cell types [30], [31], [32].

However, subsequent to the initial establishment of the IHBD system, Notch is not required for the maintenance of the number of ductal structures per portal vein.

Similar to its function in the embryonic nervous system, Notch signaling promotes FCM fate by blocking the acquisition of FC fate in surrounding myoblasts (Bour et al., 2000).

In the haematopoietic system, Notch signalling has been known to be important for the proper development of the lymphoid compartment; Notch1, in particular, is known to be crucial for T-cell specification over B-cell lineage, whereas Notch2 is known to be required for B-cell development.

The U.S. healthcare system notched another dubious honor in a new comparison of its quality to the systems of 10 other developed countries: its rank was dead last. .

However, in both systems, Notch signaling promotes differentiation toward luminal epithelial cells.

In other developing systems, Notch signaling has been shown to effect lineage commitment as well as stem cell self-renewal [ 20, 24- 26].

In other systems, Notch signaling has been shown to play an important role in cell-fate determination, as well as in cell survival and proliferation [ 6, 7].

We propose that in the mammary gland, as has been reported in other developmental systems, Notch activation acts as a regulator of asymmetric cell-fate decisions.

On the basis of atomic fracture mechanics accounting for atomic discreteness, surprisingly, the Griffith-based criterion which is originally proposed for cracks describes brittle fracture well in non-crack systems (notches) even below the critical size.