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A typical synthetic procedure is as follows.

However, a slight modification was made to the synthetic procedure.

Fig. 1 Synthetic procedure of GNR-SiO2-Ab.

Applied synthetic procedure induced formation of pure rutile crystalline structure.

Graphical abstract The improved synthetic procedure of lesinurad (I).

Scheme 5 The improved synthetic procedure of lesinurad (I).

The overall synthetic procedure was described in Scheme 1.

The synthetic procedure was illustrated in Scheme 1.

The overall synthetic procedure is illustrated in Fig. 2.

The general synthetic procedure is shown in Figure 1.

A typical synthetic procedure is carried out as follows.

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