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The InEK was able to increase the sample of calculating hospitals, supporting high calculation standards concerning resource allocation at hospital level, but facing methodological problems concerning tariff calculation at national level, such as comparability or inlier calculation issues.

Moreover, a number of limitations of ICC, such as comparability of populations and its dependence on the covariance between observers, described above, are also present in CCC 16.

Through the use of regulatory mechanisms, such as comparability protocols, it may be possible to reduce the reporting requirements for these changes.

We focus on methodological issues such as comparability, validity, (dis- agreement between methodis- agreement predict concentrations in earlier or later periods, and timing of exposure assessment that are relevant to several exposures rather than exposure-specific issues.

Our study has many characteristics that contribute to the validity of the results, such as comparability at baseline, adherence to interventions and the use of one outcome assessor to minimise noise due to problems of interobserver reproducibility.

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Individual experiences need to be reworked to fit such criteria as comparability and objectivity.

We also assessed methodological heterogeneity by examining differences between studies in methodological factors such as the comparability of groups.

We address central measurement concepts such as generalizability, score comparability, and issues of dimensionality.

Clinicians will likely seek out practice guidelines and position statements from established scientific societies to help evaluate key information regarding biosimilars, such as efficacy, safety, comparability, and interchangeability with the reference biologic.

As such the comparability of values of HRQoL produced by different instruments in patients with depression is unclear.

While a consensus amongst all brands is unlikely in the short term, Kibbey believes that what may speed up the pace of change is the European Commission's product environmental footprint proposals, which provide principles for communicating sustainability performance, such as transparency, reliability, completeness, comparability and clarity.

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